Satoshi, luego de haber quedado entre los 4 mejores entrenadores de Shinô, se va de vacaciones con su madre y el profesor Yukinari Ookido, a la región de isshu. En esta aventura se les une iris, una chica salvaje. Satoshi al observar a los pokemon de la zona, decide participar en la liga de la region.

Pokémon Best Wishes! (Poketto Monsutā Besutouisshu, nombre en japonés) es el nombre de la decimocuarta temporada de Pokémon. En esta nueva temporada y generación (5ta generación), Ash y su Pikachu comienzan su viaje por la Región Isshu. En su camino, se hacen dos nuevos compañeros: Iris y Dento. La novedad de esta temporada son los Pokemon totalmente nuevos que aparecerán en transcurso de sus  aventuras.

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